11/29/2023 0 Comments Apk galaxy avg cleaner pro![]() ► Cache cleaner: Clear out app cache, temporary files and leftover data ![]() ► RAM cleaner: Clean RAM and boost performance of your phone in a few taps ► App remover: Easily remove apps that slow down your device ► App analyzer: AVG Cleaner can identify apps that consume your battery, drain mobile data, or take up too much storage space, allowing you to clean them out more easily ► Remove preinstalled apps: Do you have pre-installed bloatware apps you don’t need? We can prevent them from slowing down your device The booster, memory cleaner (RAM Cleaner), cache cleaner, battery saver, storage clean up, and app removal features are described below: Cleaner: Advanced app remover & app manager: With AVG Cleaner, you will enjoy a longer battery life, avoid a lagging Android device, get rid of junk files, and automatically find bad quality or duplicate photosĪVG Cleaner – Memory (RAM) Booster and Junk Cleaner is a smart analysis application and clean up tool that gives you more storage space, better performance, and longer battery life
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11/29/2023 0 Comments Enhanced push to talk iphone![]() MUSIC STREAMING – you now have a variety of options to listen to your favorite music USB port which also charges your device MP3/WMA Player and an AM/FM tuner with 30 Station presets (18 FM/12 AM).SIRI / GOOGLE VOICE ASSIST BUTTON – with the touch of a button you have the power to summon your favorite assistant (Siri or Google) and verbally speak your commands such as play music podcasts navigation etc.BUILT IN BLUETOOTH – your single DIN car stereo receiver will easily pair with the vast majority of Bluetooth devices allowing you to make and receive all your calls Hands Free and stream your favorite music.Built using high-quality materials for a long-lasting finish and maximum usability. We strive to make quality products at the lowest prices. QUALITY: After all these years we continue to manufacture products to meet our customers' needs and wants.Today’s consumers continue to choose Magnavox products to enjoy the values it stands for quality and high performance at a smart price. PERFORMANCE: The Magnavox brand is ubiquitous among popular products found in households around the world.Accessories include: Remote control (uses 1 x CR2025 battery, included) and AC/DC adapter. KEY FEATURES: Top loading CD player, total 10W RMS output (2 x 5W), programmable CD player, digital PLL FM stereo radio, decorative blue color lights, LED display, built-in USB port for audio playback, connects to any audio device via 3.5mm aux in port, EQ function, Bluetooth wireless technology and AC operation.All televisions and computer devices recovered for recycling will be processed in a manner that complies with all applicable federal, state, and county laws and requirements. COMMITMENT: Magnavox is committed to maintaining a clean environment.Connect to your smartphone, tablet or other audio device via Bluetooth or the Aux port to listen to your music, videos or games wherever you go! This Bluetooth speaker system provides premium audio you are sure to appreciate! Experience a premium audio experience in your office, bedroom, living area, or kitchen. BLUETOOTH: Magnavox speakers keep the party going come rain or shine.Allows you to play your favorite audio files from your computer's media library when you connect it directly to the amp. USB 2.0/SD Card Input ▶ - The sound amplifying mixer device features a USB/SD card input to support flash drives or SD card.But if you are connecting whith TV or PC devices, please keep the distance within 15ft/5m.) (NOTE: Please keep the distance within 30ft/10m between the device and amplifier without any wall blocking. Bluetooth 5.0 ▶ - Built-in bluetooth 5.0 core, no pop, no audible noise when Bluetooth connection is established, designed for the customers who pursue HiFi sound.Small simple compact design also for car audio system. Recommend for home TV audio, computer audio system-game, tower Speaker, garden speaker. Wide Application ▶ - Compatible with mobile phones, computers, tablets, notebooks, TVs and projectors with AV audio etc.Note: There is an isolation plastic sheet at the bottom of the remote control, which needs to be removed before use. Include controller for distant audio adjustments. Bass & Treble Control ▶- Designed with volume, treble and bass control knobs for more delicate adjustment of the sound, much fun and high playability.HiFi Stereo AMP ▶ - This Dual channel stereo digital amplifier offer 300W+300W peak power and 40W+40W rated power.LG CM4590 XBOOM XBOOM Bluetooth Audio System with 700 Watts Total Power,Black JENSEN MPR210 7 Character LCD Single DIN Car Stereo Radio | Push to Talk Assistant | Bluetooth Hands.ĭouble Din Car Stereo - Corehan 10 inch Touchscreen Car Radio Bluetooth Multimedia Player with. Raymate Bluetooth Speakers, 20W IPX7 Waterproof Speaker Wireless Bluetooth-V5.0, HiFi Stereo Sound. Sharp XL-B512 Micro Component Wireless Bluetooth Audio Streaming & CD Player Wood Speaker System +. LG Electronics Tone HBS-900 INFINIM Bluetooth Stereo Headset - Silver (Renewed) Magnavox MM442 3-Piece Top Loading CD Shelf System with Digital PLL FM Stereo Radio, Bluetooth. ![]() Sony STRDH190 2-ch Home Stereo Receiver with Phono Inputs & Bluetooth Black Stereo Audio Amplifier Receiver, 300Wx2 Home Dual Channel Bluetooth 5.0 Sound Speaker AMP, Home.īOSS Audio Systems 616UAB Multimedia Car Stereo - Single Din LCD Bluetooth Audio and Hands-Free. 11/29/2023 0 Comments Soap bible study method![]() When facing challenges, remind me that I can be strong in you. Please help me to rely on your strength, not my own. “Lord, thank you for your faithfulness and mighty power. You might thank God for His strength, ask for His help in relying on Him, confess times when you’ve tried to rely on your own strength or pray for others who need God’s strength. This is your response to God based on what you’ve learned. Or you might choose to memorize this verse, so you can recall it when you’re feeling weak or overwhelmed. How can I remind myself of God’s strength when facing challenges or when in spiritual warfare?įor example, you might spend more time praying each day, asking for God’s strength.What does relying on God’s mighty power in my daily life look like?.This is where you consider how the verse applies to your own life. The phrase “mighty power” emphasizes that God’s strength is far beyond our own.The word “finally” suggests that this is a concluding thought, something important that Paul wants to leave his readers with.The verse is a call to strength, but not in our own power – in the Lord’s power.The mindset of the Biblical authors and the times they lived in.Context (in this case, Paul is writing to the Ephesians about spiritual warfare).This is where you take time to think deeply about the verse and its meaning. You might want to use a Bible study journal or a simple piece of paper. Read your Bible verses and write down the verse or verses you’re studying. The first step in the SOAP method is scripture. Let’s use Ephesians 6:10: “ Finally, be strong in the Lord and in his mighty power.” Scripture This chapter is rich with teachings, so we’ll focus on a specific verse for our example. Help me to trust in you more fully and to share your love with those around me.” SOAP Method of Bible Study Examples Using Ephesians 6Īs another SOAP method example, I’ll walk you through the SOAP method using Ephesians 6. “Lord, thank you for your incredible love and sacrifice. Prayer in the SOAP Bible Methodįinally, the last step in the SOAP Bible method is prayer. ![]() ❣️ SOAP method in ActionĪgain, when reading John 3:16, you might be reminded of the depth of God’s love for you personally and feel called to trust in Jesus more deeply and share His love with others. This is where you consider how the Scripture passage applies to your life. Application in the SOAP Method for Bible Study ❣️ SOAP method in Actionįor our SOAP scripture example, John 3:16, you might observe that it speaks of God’s immense love for the world, His sacrifice in giving His Son, and the promise of eternal life for believers. In this step of the SOAP Bible method, you reflect on what you’ve read and make observations. ❣️ SOAP method in Actionįor example, let’s use John 3:16, “ For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life.” Step 2. This is where you start by reading a passage from the Bible. The first step in the SOAP method for Bible study is scripture. Scripture in the SOAP Method for Bible Study This approach is designed to help you connect with God’s Word personally and apply its truths to your daily life. The SOAP Bible method is an acronym that stands for: Instead of simply reading scripture, it slows you down to contemplate what you’re reading. As a Christian Bible scholar who deeply loves the Bible and our Lord Jesus Christ, I think the SOAP Bible method is a wonderful way to deepen our understanding of God’s Word. The SOAP method for Bible study is a simple yet powerful tool that can transform your engagement with scripture. Remember, prayer is a two way conversation, so be sure to listen to what God has to say! Now, write it out.4) Next Steps Introduction to the SOAP Method for Bible Study This can be as simple as asking God to help you use this scripture, or it may be a greater insight on what He may be revealing to you. Write how this scripture can apply to you today. Perhaps it is instruction, encouragement, revelation of a new promise, or corrections for a particular area of your life. Personalize what you have read, by asking yourself how it applies to your life right now. Paraphrase and write this scripture down in your own words. What struck you and caught your attention in what you read? What do you think God is saying to you in this scripture? Ask the Holy Spirit to teach you and reveal Jesus to you. When you are done, look for a verse that particularly spoke to you that day, and write it in your journal. Take time reading and allow God to speak to you. Open your Bible to today’s reading (according to whatever plan you are following). It can be used with any daily Bible reading plan. is a method of Bible reading and journaling. 11/28/2023 0 Comments A daily schedule planner![]() If you’re looking to use a daily schedule for your personal life then I recommend combining it with one of our free printable daily planner templates or printable personal planners! Free printable daily planner Simply open your favorite, save it to your device, then print and use it. Our hourly schedule template has a notes section for important information or reflections along with space for your to-do list and priorities.Ĭhoose a daily schedule template from the collection below. These schedule templates come in so many different styles so you can choose your favorite layout. If you love to stay on track then a daily schedule will definitely benefit you. These daily schedule templates are perfect for all stages of your life, whether you are in school, at work, or unemployed. Using a daily schedule template can help you streamline your daily routine and daily agenda. These daily schedule planners really are a great time management tool! Why Use a Daily Schedule Template? There is no need to cause yourself any stress by creating a daily schedule template when you can use one of ours for free. Having a strategy will allow you to manage your time more efficiently and make better progress. Why do you want to do these things? What steps will you take to complete your goal? What are your priorities? What time do you have? Then create your schedule around this. To make the most out of our daily schedule printable, we recommend spending a little time understanding your strategy. We can check the cancel box and then forget about it.How do I make a daily schedule and plan my day?Ĭhoose from this collection of daily schedule templates available in a variety of different designs to help you plan your day, including your schedule, priorities, and everything you need to do. When we become so used to routine, and the impulse says something like, “I have to do this today because it’s on the schedule, so I have to do it,” except the task doesn’t need to be completed anymore. It’s a guilt-free way to get something off our schedule. If we put a task on the schedule but it’s no longer relevant, or we don’t need to complete the task after all, we can check “Cancel”. ![]() The most common reason for missing a morning task is we might have overslept. Maybe we didn’t realize we were low on food and needed to go grocery shopping. Sometimes things happen and we can’t get to a task that day. At the bottom of each day, there’s a section called “+ Rescheduled” where you can add the task to a different day. With the “Reschedule” box, you can easily check the box and move the task to a different day. Nothing more satisfying than checking something as done off our to do list. How the Getting Organized Autistic Style Planner Works ![]() What makes it especially different are the checkboxes on the side. My planner daily visual scheduler allows you to break the days into 3 blocks of time each day. ![]() It’s named after my article by the same name Getting Organized Autistic Style: Autism & Organizational Skills. To keep myself organized, I created an organizational printable and a notebook planner called Getting Organized Autistic Style. Visual Schedule Printable & Planner for Autistic Adults ![]() For the price, XnViewMP overperforms, making it a must-have for those who are obsessed with images but don't want to pay for an image viewing, editing, and conversion application.WipeFile deletes files and folders secure and fast. To do this, WipeFile overwrites the information completely, so there is no way to restore the files or reconstruct the file content. ![]() WipeFile supports 14 different wipe methods, e.g. Languages:Ğnglish, German, Arabic, Chinese (simplified), French, Hungarian, Italian, Japanese, Korean, Polish, Portuguese, Russian, Spanish System Requirements: WinXP / Vista / Win7 / Win8 / Win10 two US Navy standards, the standard of the US Department of Defense, US Air Force and the NATO. Use 7-Zip 32bit or 7-Zip 64bit to unzip this file.Ĭlick here to visit the author's website. WireGuard® is an extremely simple yet fast and modern VPN that utilizes state-of-the-art cryptography. It aims to be faster, simpler, leaner, and more useful than IPsec, while avoiding the massive headache. It intends to be considerably more performant than OpenVPN. WireGuard is designed as a general purpose VPN for running on embedded interfaces and super computers alike, fit for many different circumstances. Initially released for the Linux kernel, it is now cross-platform (Windows, macOS, BSD, iOS, Android) and widely deployable. It is currently under heavy development, but already it might be regarded as the most secure, easiest to use, and simplest VPN solution in the industry. ![]() WireGuard aims to be as easy to configure and deploy as SSH. A VPN connection is made simply by exchanging very simple public keys – exactly like exchanging SSH keys – and all the rest is transparently handled by WireGuard. 11/28/2023 0 Comments Cheap and healthy meals![]() Seriously, this is a simple way to pack in flavor- and to use ingredients you probably already have in your pantry. But there’s nothing a rotisserie chicken and homemade dressing can’t fix. Rotisserie Chicken Salad With Homemade Balsamic Dressing But if you want them to try something new without the fuss, let them help you in the kitchen (get them to pull the noodles out of the squash and watch the magic come alive!).ģ. Pro tip: The kids will totally know the spaghetti squash noodles aren’t really noodles. Sprinkle with cheese and more fresh basil! Top the noodles with sauce (and any leftover meat you want to add).Make the spaghetti squash noodles by scraping the inside of the squash with a fork.Once the squash is done cooking (you’ll know it’s ready when you can easily pierce the flesh with a fork), remove it from the oven and let it cool for a few minutes.Then taste and add more seasonings if needed. Pour in jarred sauce and fresh basil and stir to combine. Add onion and garlic and sauté for 4–5 minutes.While the squash is doing its thing, drizzle olive oil in a saucepan over medium heat.Drizzle with olive oil and sprinkle with salt and pepper.Cut the spaghetti squash in half and scoop the seeds out. ![]() Preheat the oven to 400 degrees F and line a sheet pan with parchment paper.Leftover ground meat or sausage, optional.Just up the fresh basil and throw in whatever dried Italian spices you have in your spice cabinet. Don’t have jarred sauce? Crushed tomatoes will do the trick too. Seriously, with jars of marinara sauce and a few pantry staples, you can serve up cheap meals that are simple, easy and tasty. When it comes to marinara, doctoring up jarred sauce is the new “ simmer for hours.” Even Grandma’s timeless recipe will approve. Easy Marinara Sauce With Spaghetti Squash Noodles When buying, look for options-whether corn or flour-that have a small list of ingredients (try to keep it under five).Ģ. Plus, they’re typically cheaper than flour tortillas. Corn tortillas usually have less yucky ingredients and are naturally gluten-free for folks who need to avoid gluten. Pro tip: When it comes to tortillas, not all are created equal. Over medium heat, warm up tortillas in a skillet, about 1 minute per side.When the chicken is fully cooked to at least 165 degrees F, pull it apart using two forks.Pour the salsa on top, covering all the chicken.Rub both sides of the chicken with the taco seasoning, then place the chicken in the slow cooker.Optional toppings: a sprinkle of cheese, avocado slices, diced red onion, chopped romaine lettuce or toasted pumpkin seeds.2 pounds boneless, skinless chicken breasts.These are great plain, but they’re also easy to dress up if you have company coming over or you have some almost-gone-bad food lingering in your fridge or pantry. They work any night of the week-and even better? They taste amazing as lunch leftovers the next day. You don’t have to wait for Taco Tuesday to make these beauties. Rotisserie Chicken Salad With Homemade Balsamic Dressing. ![]() Easy Marinara Sauce With Spaghetti Squash Noodles. ![]() Here are some of our favorites to get you started-in no particular order of yumminess. Cheap and healthy meals that you’ll love ( and so will your budget). All you need are some staple recipes, a dash of creativity, and a good pinch of “I can do this!” Then-voilà. It’s tough!Įven if you try to stick to your list in the store, meal prep for the week, and only buy generic brands, it can still be tricky to find cheap, healthy recipes that don’t bust your budget.īut guess what? It’s totally doable. We all know the easiest place to go over budget is your grocery bill-especially if you’re trying to take the healthy route. Cheap, healthy meals? We know what you might be thinking: Is that even possible? (Not-so-subtle hint: It actually is!) 11/28/2023 0 Comments Remotepc free discontinuedPreferences: Manage wallpapers, themes, fonts etc and change the proxy settings.RemotePC Web Access: Log in to your RemotePC web account.How do I wake up an offline remote computer via WOL? How can I configure Proxy Settings to use the RemotePC application? How can I delete desktop shortcuts for my remote computer?Ĭan I drag and drop files/folders between my local and remote computer? How can I create desktop shortcuts for my remote computer? How can I rename or remove configured computers from my account? Is it possible to move computers between groups?Ĭan I remove or rename a computer from within a group?Ĭan I print documents on my remote computer?Ĭan I use the RemotePC application via VPN (Virtual Private Network)?Ĭan I end an ongoing session when my computer is getting accessed? What is a Group? How can I create a Group? What should I do?Ĭan I use keyboard shortcuts (such as Ctrl + C) on my remote computer during a remote session?Ĭan I block keyboard and mouse input for remote computers?Ĭan I redirect my local microphone input to the apps/services on the remote computer? I can not hear audio from my remote Linux machine. How do I use Whiteboard during a remote session?Ĭan I play music and watch video on the remote computer? How do I transfer files / folders without starting a remote session?Ĭan I record the remote session activities?Ĭan I make notes on my remote computer screen? If yes, how? How do I disconnect a remote session on a Linux machine?Ĭan I scale the remote computer's desktop screen to fit within my local computer window?Ĭan I switch between multiple monitors of the remote computer?ĭoes RemotePC support multi screens (monitors)? How do I clear stored personal key credentials from the desktop application? I forgot the Personal Key of my computer. What do the options under 'Always-ON Remote Access' tab signify? How do I connect to a specific RDP Session on a server? How do I view and access my remote computers?Ĭan multiple simultaneous connections be established with the same remote computer?Ĭan I remotely access a Mac from a Windows or Linux computer? How do I configure my computer for remote access? What happens when I clone computers and VMs with RemotePC pre-installed? How can I restart my Mac system that is FileVault enabled? What should I do to restart a remote computer? ![]() What are the different states of RemotePC? What are the options available in the RemotePC tray? On trying to install the RemotePC Windows application I'm getting the message "The App You're Trying To Install Isn't A Microsoft-Verified App". How to enable RemotePC related background items for Mac OS Ventura 13.0? ![]() ![]() How do I pre-authorize RemotePC in Mac OS Catalina for access to files and folders? How do I pre-authorize RemotePC in Mac OS Catalina for remote access? How can I avoid my remote Linux machine from going offline after reboot?Ĭan I access my Raspberry Pi computers with RemotePC?ĭo I need to pre-authorize RemotePC in Mac OS Mojave for remote access? Which distributions/versions of Linux OS are supported for the RemotePC application?ĭo I need a monitor to remotely access a Linux server?Ĭan I remotely access a Linux machine running on Wayland desktop session?Ĭan I launch the RemotePC Linux application at the root level? Which version of Mac OS X is supported for the RemotePC application? What are the checks to be made before connecting to a remote computer? What are 'Computer Name' and 'Personal Key'? If your question is not addressed below, please contact us through our feedback form and we'll get back to you shortly. ![]() Finally, the Gold Saucer is also home to a lot of outlandish and subdued outfits, as well as a game to challenge your fashion skills called ‘Fashion Report. Beast Tribes also have a few pieces such as dyeable finger nails from the Ananta in The Fringes area. It’s also worth heading to the Wolve’s Den and taking part in some PvP to find some beautiful armour pieces that a lot of people don’t realise are there. Basic Value 24 Patch 2.2 This crystalline prism captures the likeness of a piece of equipment and projects it onto another object of comparable form and function. A lot of older Final Fantasy cosplay pieces, such as Squal’s jacket from FFVIII, are Veteran Rewards and can be traded for with Achievement Certificates (earned by playing the game over time) by Jonathas in Old Gridania. Now where do you actually get outfits? You can buy basic armour from towns as you level with rarer pieces from dungeons, but the most sought-after looks are either crafted or from events and quests. To apply it you just need to click ‘Apply’-this can be done from the dresser, but also from the Character menu by clicking on the plates icon next to the gear sets list.īy using Glamour Plates like this you can use the same look for multiple Jobs and quickly update your look when levelling and replacing gear to keep your appearance consistent. To form a Glamour Plate select ‘Edit Glamour Plates’ and fill each slot with the look you want from the dresser, then click save. Plates let you form a whole outfit and apply it all at once to what you’re wearing. This guide will explain how to adjust the UI, and offer tips to help you navigate the game. ![]() The UI in FFXIV can be adjusted in myriad ways to ensure an enjoyable gaming experience. Using the dresser will allow you to store up to 400 pieces of gear-handy for all of the hoarders out there-and easily cast any stored item’s appearance over a selected one you’re wearing, but it’s real power lies in FFXIV Glamour Plates. The user interface, or UI for short, refers to the various on-screen elements and menus through which a player interacts with the game. If you’re a fashion aficionado and want to set up multiple outfits, make use of the Glamour Dresser and Glamour plates which can be found in Inn rooms in all of the major cities. This means you can register the look of an item and then take it out of the dresser by right-clicking on it and pressing Restore.(Image credit: Square Enix) How to use the FFXIV Glamour Dresser and Plates After that, the item will enter the available glamour list and will be usable in Glamour Plates infinitely. ![]() Once unlocked you will be able to access the Glamour Dresser in any Inn of the game and start creating your own styles.įirst of all, the Glamour Dresser allows you to register the look of an item in exchange for a Glamour Prism. 60 Gear (DoW) Purchase Job-specific Gear - Purchase Lv. 50 Gear (DoM) Purchase Job-specific Gear - Purchase Lv. 50 Gear (DoW) Purchase Job-specific Gear - Purchase Lv. 50 Arms & Tools Purchase Job-specific Gear - Purchase Lv. To unlock Glamour Plates you will first need to complete the quest "If I Had a Glamour" given by Swyrgeim in Western Thanalan (X:12.6 Y:14.3). Calamity Salvager (Mih Khettos Amphitheatre)s other shops: Purchase Job-specific Gear - Purchase Lv. Grand company, dont buy off market board thats a. Youll get more than youll ever need, max out your grand company and level in the process. Glamour Plates can be applied anytime for free, as long as you can wear the piece you're trying to get the look from and that you're in a major city. If you havent leveled your tanks yet, do the duty routletts and farm the company seals from their completion, then exchange the seals for glamour prisms and whatever else you could want. Glamour Plates, on the other hand, can be considered a register of specific glamour sets that you will be able to cast on your equipment without paying for the glamour prism and dyes other than their initial purchase. This mechanic allows players to wear their classic equipment, but change its look. If you're tired of your plated armor in Final Fantasy XIV and want to wear something else, that's possible thanks to the Glamour system. 11/28/2023 0 Comments Amd zen 4 vs alder lake![]() I'm actually surprised if this is not bs or there is not an iGPU, why the power increase on common desktop CPUs? Plus, your 11700 is 8 cores, 170W should be 16 cores. Gaming is generally a light load most modern CPUs don't push over 25% performance.ĭo a render or some other intensive task and measure the real consumption when the CPU is at 100%. My 11700 uses about 40-45 during gaming, my old 4770K used 95 ^^ The second quarter results for AMD ended strong, during the Q2 presentations the company also talked about upcoming products a bit. That includes the first 7nm processors based on the Zen 2 archite. The theory is that the FMA3 supplem.ĪMD Zen 2 nm architecture starts with EPYC CPUs - Talks 5nm also - 07:50 AM In an interesting find, it has been discovered that AMD processors based on ZEN architecture actually support the latest iteration of FMA, the FMA4-instruction set. Last week Intel announced a 48-core pr.įMA4 instruction set hidden, but is working on AMD Zen processors - 11:06 AM So if you have been following yesterdays' announcement, you will have noticed that AMD has talked about Zen2 and actually announced a new processor based on it. Well, the yield of the Z.ĪMD Zen 2 "Rome" 64-core processor Photo up close - 09:29 AM So if a wafer has 200 CPUs dies and 50 are functional, your yield is 25%. Whenever you fab a wafer with CPU/GPU dies (or whatever they are fabbing), there are always defects. The new AIDA64 update introduces optimized benchmarks for AMD Ryzen 5000 Series processors, monitoring of EVGA iCX3 sensor values, and supports the latest AMD and Intel CPU platforms as well as the ne.ĪMD Zen 2: Production yields for Ryzen 3000 Dies at 70 percent - 09:08 AM ![]() FinalWire AIDA64 v6.32 with AMD Zen 3 and RX 6000 Support - 09:41 AM 11/28/2023 0 Comments Proton jon drive thru![]() ![]() This involves exploring different methods of isolation. One area of interest for the induction of natural products through co-culture microbial communication through small molecules.Ĭurrently, we have explored some microbial interactions within co-culture conditions, but need to develop a way to discover the small molecules utilized in the microbial communication process. ![]() This discovery has sparked significant interest in probing microbial genomes for new and bioactive natural products. Over the last decade, analysis of microbial genomes has demonstrated that only a fraction of the possible microbial secondary metabolites have been explored. However, the difficulty in discovery and isolation of natural products has caused a shift in development of pharmaceutical drug leads (i.e. Since 1980, greater than 60% of drugs developed were derived from natural sources. Secondary metabolites (natural products) have had a long, rich history with respect to their importance in the treatment of disease. Project 2: Elucidating Changes in Antimicrobial Production of Streptomyces sps. This project applies proton nuclear magnetic resonance ( 1H-NMR) and visible spectroscopy as means to monitoring the weak acid-weak base interaction and to quantify the pK a by proton integration and wavelength absorbance changes, respectively. Challenges in determining the pKa’s of these ligands include monitoring the equilibrium of a weak acid-weak base chemical reaction and the use of different methods in determining the acidity of a proton in organic solvent conditions, since common aqueous methods are not possible. Our project’s goal is to quantify the changes in pK a of previously synthesized glycine containing ligands with the presence or absence of electron withdrawing groups attached to the molecule in organic solvents. The use of electron withdrawing groups is a well-known approach to change the chemical properties of a molecule, including the acidity. Project 1: Method Development and Determination of Glycine Metal Complex pKa’s by NMR and Visible Spectroscopy Chemistry and Biochemistry, University of Oklahoma Chemistry and Biochemistry, University of OklahomaĢ011 – Ph.D. Chemistry, Emporia State UniversityĢ009 – M.S. |
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